Objective: A remarkably sensitive. accurate. and efficient ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach was developed as a facile and expeditious method for measuring cilofexor concentration in beagle dogs. the herb-drug interactions between silybinin and cilofexor was explored based on pharmacokinetics. https://themightyhobbyers.shop/product-category/tee/