Abstract Background Patients with polycystic ovarian syndrome (PCOS) are associated with known alterations in mitochondria DNA copy number (mtDNA-CN). The aim of this study is to study the change in mtDNA-CN in patients with PCOS who were treated with metformin. Methods This is a prospective cohort of patients with PCOS. who received metformin for one year. https://safeersappliancers.shop/product-category/miele-da3496-89-cm-canopy-cooker-hood-stainless-steel/