Ineffective hematopoiesis is the major characteristic of early myelodysplastic syndromes. Its pathophysiology relies on a diversity of mechanisms supported by genetic events that develop in aging hematopoietic stem cells. Deletion and mutations trigger epigenetic modifications. and co-transcriptional and post-transcriptional deregulations of gene expression. https://www.roneverhart.com/Dudley-ASA-Thunder-ZN-Hycon-12-52-300-Softballs-4A-068Y/