Challenge with specific microbial stimuli induces long lasting epigenetic changes in innate immune cells that result in their enhanced response to a second challenge by the same or unrelated microbial insult. a process referred to as trained immunity. This opens a new avenue in vaccinology to develop Trained Immunity-based Vaccines (TIbV). defined as vaccine formulations that induce t... https://www.roneverhart.com/Tiamat-s-Rebuke-East-Non-Ladder/